At least 19 people have died as violent protests erupted on the streets of Pakistan's main cities in anger at an anti-Islam film made in the US.
Fourteen people were killed in the port city of Karachi and a further five died in the north-western city of Peshawar, hospital officials said.
Protesters clashed with police outside the diplomatic enclave in the capital, Islamabad, near the US embassy.
There has been widespread unrest over the amateur film, Innocence of Muslims.
Dozens of people have been reported wounded and BBC correspondents said some were in a critical condition.
Protests have already left several people dead around the world, including Pakistan, where the government had appealed in advance for peaceful protests, declaring a holiday and "day of love" for the Prophet Muhammad.
Although US targets have borne the brunt of protests against the film, anti-Western sentiment has been stoked further by caricatures of the Prophet Muhammad published this week in the satirical French magazine, Charlie Hebdo.
France shut embassies and other missions in around 20 countries across the Muslim world on Friday.
Protests were banned in France itself and in Tunisia, where France is the former colonial power, but there were widespread demonstrations elsewhere.
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